Clinical Studies on Annatto Tocotrienol’s Effect on Inflammatory Markers
|A.||Clinical Study on Annatto Tocotrienol’s Effect on Lipid Parameters|
Open label study examining various dosages of tocopherol-free tocotrienol from annatto indicated the optimum dose to lower total cholesterol, LDL, triglycerides and cytokines associated with cardiovascular disease to be 250mg/day.
Qureshi AA et al. Dose-dependent modulation of lipid parameters, cytokines and RNA by δ-tocotrienol in hypercholesterolemic subjects restricted to AHA Step-1 diet British Journal of Medicine & Medical Research 6(4): 351-366, 2015, Article no. BJMMR.2015.211 Read More
|B.||Clinical Study on Annatto Tocotrienol’s Effect on Inflammatory Markers|
Open label study examining various dosages of tocopherol-free tocotrienol from annatto indicated the optimum dose to lower inflammation markers to be 250mg/day.
Qureshi AA et al. Impact of δ-tocotrienol on inflammatory biomarkers and oxidative stress in hypercholesterolemic subjects. Clinical & Experimental Cardiology 2015 vol. 6, Issue 4 Read More
|C.||Design of Clinical Study on Annatto Tocotrienol’s Effect on Bone Markers (study results to be published fall 2017)|
Double-blind placebo-controlled study of 89 subjects examining the impact of tocotrienols on bone health in dosages of 300 and 600 mg/day of tocopherol-free tocotrienol from annatto.
Shen C-L, Mo H, Yang S, et al. Safety and efficacy of tocotrienol supplementation for bone health in postmenopausal women: protocol for a dose– response double-blinded placebo-controlled randomised trial. BMJ Open 2016;6:e012572.doi:10.1136/bmjopen-2016-012572 Read More
|D.||Anti-Inflammatory Formulation Clinical Studies|
These clinical studies show that delta-tocotrienol in combination with antioxidant polyphenols curb inflammation and manage dyslipidemia. One of the placebo-controlled studies was conducted in two groups of elderly subjects, one with normal and the other with elevated lipid levels. The product formulation was composed of delta-tocotrienol from annatto, along with a B-vitamin (niacin) and polyphenols. In both groups, supplementation led to a significant drop in C-reactive protein (a predictor for chronic inflammation) and γ-glutamyl-transferase (a predictor for non-fatal myocardial infarction and fatal coronary heart disease), while increasing total antioxidant status, a measure of the body’s capacity to counteract reactive oxygen species. In the hypercholesterolemic group, LDL cholesterol (20-28%) and triglycerides (11-18%) also dropped. C-reactive protein dropped in healthy elderly (21-29%) as well as lipidemic elderly (31-48%), as did γ-glutamyl-transferase (14-20%). Notably, there were no adverse effects associated with the 6-week supplementation period.
Qureshi AA et al. Nutritional supplement-5 with a combination of proteasome inhibitors (resveratrol, quercetin, δ-tocotrienol) modulate age-associated biomarkers and cardiovascular lipid parameters in human subjects Clinical & Experimental Cardiology 2013 col. 4, issue 3 Read More
Qureshi AA, Khan DA, Mahjabeen W, Papasian CJ, Qureshi N (2012) Suppression of nitric oxide Production and cardiovascular risk factors in healthy seniors and hypercholesterolemic subjects by a combination of polyphenols and vitamins. J Clin Exp Cardiolog S5:008. doi:10.4172/2155-9880.S5-008 Read More
An open-label randomized trial involving DeltaGold (125, 250, 500, 750, and 1,000 mg/d dosage groups) confirmed the bioavailability of tocopherol-free annatto tocotrienol. Delta- and gamma-tocotrienols are readily bioavailable if taken with a meal.
Qureshi AA, Khan DA, Saleem S, Silswal N, Trias AM, et al. (2015) Pharmacokinetics and bioavailability of annatto δ-tocotrienol in healthy fed subjects. J Clin Exp Cardiolog 6: 411. doi:10.4172/2155-9880.1000411 Read More
|F.||Omega-3 Protection (Antioxidant)|
200-500ppm tocotrienol from annatto offers superior antioxidant protection of fish oil versus tocopherol-tocotrienol mixtures, or alpha-tocopherol.
Zou Z, Akoh C Antioxidant activities of annatto and palm tocotrienol-rich fractions in fish oil and structured lipid-based infant formula emulsion Food Chemistry 168 (2015) 504–511 Read More