Related Studies

Clinical Studies on Annatto Tocotrienol’s Effect on Inflammatory Markers​

A.Clinical Study on Annatto Tocotrienol’s Effect on Lipid Parameters

Open label study examining various dosages of tocopherol-free tocotrienol from annatto indicated the optimum dose to lower total cholesterol, LDL, triglycerides and cytokines associated with cardiovascular disease to be 250mg/day.

 

Qureshi AA et al. Dose-dependent modulation of lipid parameters, cytokines and RNA by δ-tocotrienol in hypercholesterolemic subjects restricted to AHA Step-1 diet British Journal of Medicine & Medical Research 6(4): 351-366, 2015, Article no. BJMMR.2015.211  Read More

 B.Clinical Study on Annatto Tocotrienol’s Effect on Inflammatory Markers

Open label study examining various dosages of tocopherol-free tocotrienol from annatto indicated the optimum dose to lower inflammation markers to be 250mg/day.

 

Qureshi AA et al. Impact of δ-tocotrienol on inflammatory biomarkers and oxidative stress in hypercholesterolemic subjects. Clinical & Experimental Cardiology 2015 vol. 6, Issue 4  Read More

 C.Design of Clinical Study on Annatto Tocotrienol’s Effect on Bone Markers (study results to be published fall 2017)

Double-blind placebo-controlled study of 89 subjects examining the impact of tocotrienols on bone health in dosages of 300 and 600 mg/day of tocopherol-free tocotrienol from annatto. 

Shen C-L, Mo H, Yang S, et al. Safety and efficacy of tocotrienol supplementation for bone health in postmenopausal women: protocol for a dose– response double-blinded placebo-controlled randomised trial. BMJ Open 2016;6:e012572.doi:10.1136/bmjopen-2016-012572  Read More

 D.Anti-Inflammatory Formulation Clinical Studies

These clinical studies show that delta-tocotrienol in combination with antioxidant polyphenols curb inflammation and manage dyslipidemia. One of the placebo-controlled studies was conducted in two groups of elderly subjects, one with normal and the other with elevated lipid levels. The product formulation was composed of delta-tocotrienol from annatto, along with a B-vitamin (niacin) and polyphenols. In both groups, supplementation led to a significant drop in C-reactive protein (a predictor for chronic inflammation) and γ-glutamyl-transferase (a predictor for non-fatal myocardial infarction and fatal coronary heart disease), while increasing total antioxidant status, a measure of the body’s capacity to counteract reactive oxygen species. In the hypercholesterolemic group, LDL cholesterol (20-28%) and triglycerides (11-18%) also dropped. C-reactive protein dropped in healthy elderly (21-29%) as well as lipidemic elderly (31-48%), as did γ-glutamyl-transferase (14-20%). Notably, there were no adverse effects associated with the 6-week supplementation period.

 

Qureshi AA et al. Nutritional supplement-5 with a combination of proteasome inhibitors (resveratrol, quercetin, δ-tocotrienol) modulate age-associated biomarkers and cardiovascular lipid parameters in human subjects Clinical & Experimental Cardiology 2013 col. 4, issue 3  Read More

Qureshi AA, Khan DA, Mahjabeen W, Papasian CJ, Qureshi N (2012) Suppression of nitric oxide Production and cardiovascular risk factors in healthy seniors and hypercholesterolemic subjects by a combination of polyphenols and vitamins. J Clin Exp Cardiolog S5:008. doi:10.4172/2155-9880.S5-008  Read More 

E.Pharmacokinetics

An open-label randomized trial involving DeltaGold (125, 250, 500, 750, and 1,000 mg/d dosage groups) confirmed the bioavailability of tocopherol-free annatto tocotrienol. Delta- and gamma-tocotrienols are readily bioavailable if taken with a meal.

 

Qureshi AA, Khan DA, Saleem S, Silswal N, Trias AM, et al. (2015) Pharmacokinetics and bioavailability of annatto δ-tocotrienol in healthy fed subjects. J Clin Exp Cardiolog 6: 411. doi:10.4172/2155-9880.1000411  Read More

F.Omega-3 Protection (Antioxidant)
 

200-500ppm tocotrienol from annatto offers superior antioxidant protection of fish oil versus tocopherol-tocotrienol mixtures, or alpha-tocopherol.

 

Zou Z, Akoh C Antioxidant activities of annatto and palm tocotrienol-rich fractions in fish oil and structured lipid-based infant formula emulsion Food Chemistry 168 (2015) 504–511  Read More

*Please consult with your physician before using any product discussed within this website. These statements have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Individual results may vary.